Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection

Vendrame, Célia M.V.; Souza, Luana D.; Carvalho, Márcia D.T.; Salgado, Kátia; Carvalho, Edgar M.; Goto, Hiro

doi:10.1016/j.trstmh.2010.03.007

« Previous Next »Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 104, Issue 8 , Pages 566-568, August 2010

Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection

Célia M.V. Vendrame
- Laboratório de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Avenida Dr. Enéas de Carvalho Aguiar n° 470, prédio II, 4° andar, CEP 05403-000, São Paulo, SP, Brazil
- Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil
Luana D. Souza
- Laboratório de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Avenida Dr. Enéas de Carvalho Aguiar n° 470, prédio II, 4° andar, CEP 05403-000, São Paulo, SP, Brazil
Márcia D.T. Carvalho
- Laboratório de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Avenida Dr. Enéas de Carvalho Aguiar n° 470, prédio II, 4° andar, CEP 05403-000, São Paulo, SP, Brazil
Kátia Salgado
- Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil
Edgar M. Carvalho
- Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil
Hiro Goto
- Laboratório de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Avenida Dr. Enéas de Carvalho Aguiar n° 470, prédio II, 4° andar, CEP 05403-000, São Paulo, SP, Brazil
- Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
- Corresponding author. Tel.: +55 11 3061 7023; fax: +55 11 3061 8270.

Received 19 September 2009; received in revised form 25 March 2010; accepted 25 March 2010.

Summary

Arginase activity has been related to leishmaniasis development, thus we studied the constitutive and insulin-like growth factor (IGF) I-induced arginase activity of Leishmania (Viannia) braziliensis isolates from patients with different clinical forms of American tegumentary leishmaniasis (ATL). Isolates from mucosal leishmaniasis presented higher basal levels of arginase activity than isolates from other clinical forms of ATL. Isolates from disseminated leishmaniasis that present mucosal lesion in some cases reached the arginase activity similar to that of isolates from mucosal leishmaniasis upon IGF-I stimulation. Differences in arginase activity may influence disease outcomes such as evolution to mucosal lesion in patients with L. (V.) braziliensis infection.

Keywords: Leishmania braziliensis, Cutaneous leishmaniasis, Mucosal leishmaniasis, Disseminated leishmaniasis, Arginase, Insulin-like growth factor I