Toxicity of a novel suspension concentrate of niclosamide against Biomphalaria glabrata

Dai, Jian-rong; Coles, Gerald C.; Wang, Wei; Liang, You-sheng

doi:10.1016/j.trstmh.2009.07.015

« Previous Next »Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 104, Issue 4 , Pages 304-306, April 2010

Toxicity of a novel suspension concentrate of niclosamide against Biomphalaria glabrata

Jian-rong Dai
- Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory on Molecular Biology of Parasites, Jiangsu Provincial Key Subject on Parasitic Diseases, Wuxi 214064, Jiangsu Province, People's Republic of China
- Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, BS40 5DU, UK
Gerald C. Coles
- Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, BS40 5DU, UK
Wei Wang
- Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory on Molecular Biology of Parasites, Jiangsu Provincial Key Subject on Parasitic Diseases, Wuxi 214064, Jiangsu Province, People's Republic of China
You-sheng Liang
- Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory on Molecular Biology of Parasites, Jiangsu Provincial Key Subject on Parasitic Diseases, Wuxi 214064, Jiangsu Province, People's Republic of China
- Corresponding author. Tel.: +86 510 8551 1721; fax: +86 510 8551 0263.

Received 23 March 2009; received in revised form 1 July 2009; accepted 1 July 2009.

Summary

As a new suspension concentrate of niclosamide (SCN) was more effective in controlling Oncomelania snails than a wettable powder of the same drug, it was tested against Biomphalaria glabrata. There were no differences in the effect of the suspension concentrate, the wettable powder of niclosamide and ball-milled pure niclosamide against the adult snails, but at after 48h 0.125mg/l SCN killed 100% of eggs compared with 84.3% for WPN and 17.7% for pure niclosamide. Because of the improved handling characteristics of SCN over the other formulations, further field tests on Biompharia and Bulinus species are warranted.