Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 102, Issue 12 , Pages 1176-1180 , December 2008

GB virus infection: a silent anti-HIV panacea within?

Received 6 March 2008 ,Revised 24 April 2008 ,Accepted 24 April 2008.

References 

  1. Alter HJ, Nakatsuji Y, Melpolder J, Wages J, Wesley R, Shih JW, et al. The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease. N. Engl. J. Med. 1997;336:747–754
  2. Bhatnagar, N., Moenkemeyer, M., Hong, H., Schimidt, R., Heiken, H., 2007. Plasmacytoid dendritic cells expressing CD40+ and CD83+ are increased in HIV-1 patients with GBV-C co-infection, in: 14th Conference on Retroviruses and Opportunistic Infections (CROI); 25–28 February 2007; Los Angeles, CA [Abstract 928].
  3. Björkman P, Nauclér A, Winqvist N, Mushahwar I, Widell A. A case–control study of transmission routes for GB virus C/hepatitis G virus in Swedish blood donors lacking markers for hepatitis C virus infection. Vox Sang. 2001;81:148–153
  4. Björkman, P., Flambolc, L., Naucler, A., Wallmark, VE., Widell, A., 2003. GB virus C viremia during the natural course of HIV-1 infection: viremia at diagnosis does not predict mortality, in: 10th Conference on Retroviruses and Opportunistic Infections (CROI); 10–14 February 2003; Boston, MA [Abstract 157].
  5. Chang Q, McLinden JH, Stapleton JT, Sathar MA, Xiang J. Expression of GB virus C NS5A protein from genotypes 1, 2, 3 and 5 and a 30 aa NS5A fragment inhibit human immunodeficiency virus type 1 replication in a CD4+ T-lymphocyte cell line. J. Gen. Virol. 2007;88:3341–3346
  6. Dawson GJ, Schlauder GG, Pilot-Matias TJ, Thiele D, Leary TP, Murphy P, et al. Prevalence studies of GB virus-C infection using reverse transcriptase-polymerase chain reaction. J. Med. Virol. 1996;50:97–103
  7. Heringlake S, Osterkamp S, Trautwein C, Tillmann HL, Böker K, Muerhoff S, et al. Association between fulminant hepatic failure and a strain of GB virus C. Lancet. 1996;348:1626–1629
  8. Kennedy N, Tong CYW, Beeching NJ, Lamden K, Williams H, Mutton KJ, et al. Hepatitis G virus infection in drug users in Liverpool. J. Infect. 1998;37:140–147
  9. Leary TP, Muerhoff AS, Simons JN, Pilot-Matias TJ, Erker JC, Chalmers ML, et al. Sequence and genomic organization of GBV-C: a novel member of the Flaviviridae associated with human non-A–E hepatitis. J. Med. Virol. 1996;48:60–67
  10. Lefrère JJ, Roudot-Thoraval F, Morand-Joubert L, Brossard Y, Parnet-Mathieu F, Mariotti M, et al. Prevalence of GB virus type C/hepatitis G virus RNA and of anti-E2 in individuals at high or low risk for blood-borne or sexually transmitted viruses: evidence of sexual and parenteral transmission. Transfusion. 1999;39:83–94
  11. Linnen J, Wages J, Zhang-Keck Z-Y, Fry KE, Krawczynski KZ, Alter H, et al. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science. 1996;271:505–508
  12. Lui KJ, Darrow WW, Rutherford GW. A model-based estimate of the mean incubation period for AIDS in homosexual men. Science. 1988;240:1333–1335
  13. Moaven LD, Hyland CA, Young IF, Bowden DS, McCaw R, Mison L, et al. Prevalence of hepatitis G virus in Queensland blood donors. Med. J. Aust. 1996;165:369–371
  14. Nattermann J, Nischalke HD, Kupfer B, Rockstroh J, Hess L, Sauerbruch T, et al. Regulation of CC chemokine receptor 5 in hepatitis G virus infection. AIDS. 2003;17:1457–1462
  15. Nunnari G, Nigro L, Palermo F, Attanasio M, Berger A, Doerr HW, et al. Slower progression of HIV-1 infection in persons with GB virus C co-infection correlates with an intact T-helper 1 cytokine profile. Ann. Intern. Med. 2003;139:26–30
  16. Patterson S, Robinson SP, English NR, Knight SC. Subpopulations of peripheral blood dendritic cells show differential susceptibility to infection with a lymphotropic strain of HIV-1. Immunol. Lett. 1999;66:111–116
  17. Patterson S, Rae A, Hockey N, Gilmour J, Gotch F. Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus. J. Virol. 2001;75:6710–6713
  18. Puig-Basagoiti F, Cabana M, Guilera M, Gimenez-Barcons M, Sirera G, Tural C, et al. Prevalence and route of transmission of infection with a novel DNA virus (TTV), hepatitis C virus, and hepatitis G virus in patients infected with HIV. J. Acquir. Immune Defic. Syndr. 2000;23:89–94
  19. Radkowski M, Kubicka J, Kisiel E, Cianciara J, Nowicki M, Rakela J, et al. Detection of active hepatitis C virus and hepatitis G virus/GB virus C replication in bone marrow in human subjects. Blood. 2000;95:3986–3989
  20. Reed KE, Rice CM. Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties. Curr. Top. Microbiol. Immunol. 2000;242:55–84
  21. Rey D, Fraize S, Vidinic J, Meyer P, Fritsch S, Labouret N, et al. High prevalence of GB virus C/hepatitis G virus RNA in patients infected with human immunodeficiency virus. J. Med. Virol. 1999;57:75–79
  22. Rowland-Jones S. Long-term non-progression in HIV infection: clinico-pathological issues. J. Infect. 1999;38:67–70
  23. Ryt-Hansen R, Katzenstein TL, Gerstoft J, Eugen-Olsen J. No influence of GB virus C on disease progression in a Danish cohort of HIV-infected men. AIDS Res. Hum. Retroviruses. 2006;22:496–498
  24. Sabin CA, Devereux H, Kinson Z, Griffioen A, Brown D, Dusheiko G, et al. Effect of coinfection with hepatitis G virus on HIV disease progression in hemophilic men. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1998;19:546–548
  25. Sawayama Y, Hayashi J, Etoh Y, Urabe H, Minami K, Kashiwagi S. Heterosexual transmission of the GB virus C/hepatitis G virus infection to non-intravenous drug-using female prostitutes in Fukuoka, Japan. Dig. Dis. Sci. 1999;44:1937–1943
  26. Schlauder GG, Dawson GJ, Simons JN, Pilot-Matias TJ, Gutierrez RA, Heynen CA, et al. Molecular and serologic analysis in the transmission of the GB hepatitis agents. J. Med. Virol. 1995;46:81–90
  27. Schreier E, Höhne M, Kunkel U, Berg T, Hopf U. Hepatitis GBV-C sequences in patients infected with HCV contaminated anti-D immunoglobulin and among i.v. drug users in Germany. J. Hepatol. 1996;5:385–389
  28. Seipp S, Scheidel M, Hofmann WJ, Tox U, Theilmann L, Goeser T, et al. Hepatotropism of GB virus C (GBV-C): GBV-C replication in human hepatocytes and cells of human hepatoma cell lines. J. Hepatol. 1999;30:570–579
  29. Simons JN, Pilot-Matias TJ, Leary TP, Dawson GJ, Desai GJ, Desai SM, et al. Identification of two flavivirus-like genomes in the GB hepatitis agent. Proc. Natl. Acad. Sci. USA. 1995;92:3401–3405
  30. Soumelis V, Scott I, Gheyas F, Bouhour D, Cozon G, Cotte L, et al. Depletion of circulating natural type-1 interferon-producing cells in HIV-infected AIDS patients. Blood. 2001;98:906–912
  31. Stapleton JT. GB virus type C/hepatitis G virus. Semin. Liver Dis. 2003;23:137–148
  32. Tillmann HL, Heiken H, Knapile-Botor A, Heringlake S, Ockenga J, Wilber J, et al. Infection with GB virus C and reduced mortality among HIV-infected patients. N. Engl. J. Med. 2001;345:715–724
  33. Tillmann HL, Stoll M, Manns MP, Schimidt RE, Heiken H. Chemokine receptor polymorphisms and GB virus C status in HIV-positive patients. AIDS. 2002;16:808–809
  34. Toyoda H, Fukuda Y, Hayakawa T, Takamatsu J, Saito H. Effect of GB virus C/hepatitis G virus coinfection on the course of HIV infection in hemophilia patients in Japan. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1998;17:209–213
  35. Xiang J, Wunschmann S, Schmidt WN, Shao J, Stapleton JT. Full-length GB virus C (hepatitis G virus) RNA transcripts are infectious in primary CD4-positive T cells. J. Virol. 2000;74:9125–9133
  36. Xiang J, Wunschmann S, Diekema DJ, Klinzman D, Patrick KD, George SL, et al. Effect of coinfection with GB virus C (hepatitis G virus) on survival among patients with HIV infection. N. Engl. J. Med. 2001;345:707–714
  37. Xiang J, George SL, Wunschmann S, Chang Q, Klinzman D, Stapleton JT. Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MIP-1 alpha, MIP-1 beta, and SDF-1. Lancet. 2004;363:2040–2046
  38. Xiang, J., McLinden, J., Chang, Q., Klinzman, D., Kaufman, T., Montefiori, D.C., Engel, A., Hess, G., Zdunek, D., Stapleton, J.T., 2006a. Monoclonal antibodies directed against the GB virus C major envelope glycoprotein neutralize HIV infectivity differentially in PBMC than in TZB-bl cells, in: 13th Conference on Retroviruses and Opportunistic Infections (CROI); 5–8 February 2006; Denver, CO [Abstract].
  39. Xiang J, McLinden JH, Chang Q, Kaufman TM, Stapleton JT. An 85-aa segment of the GB virus type C NS5A phosphoprotein inhibits HIV-1 replication in CD4+ Jurkat T cells. Proc. Natl. Acad. Sci. USA. 2006;103:15570–15575
  40. Xiang, J., McLinden, J., Chang, Q., Kaufman, T., Stapleton, J.T., 2006c. Deletion mapping of the GB virus C nonstructural protein 5A identifies a 69 amino acid region required for inhibition of HIV replication in Jurkat cells, in: 13th Conference on Retroviruses and Opportunistic Infections (CROI); 5–8 February 2006; Denver, CO [Abstract 211].
  41. Yeo AET, Matsumoto A, Hisada M, Shih JW, Alter HJ, Goedert JJ. Effect of hepatitis G virus infection on progression of HIV infection in patients with hemophilia. Multicenter Hemophilia Cohort Study. Ann. Intern. Med. 2000;132:959–963

PII: S0035-9203(08)00205-8

doi: 10.1016/j.trstmh.2008.04.034

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 102, Issue 12 , Pages 1176-1180 , December 2008

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