Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 98, Issue 9 , Pages 514-519 , September 2004

Human schistosomiasis mansoni: intensity of infection differentially affects the production of interleukin-10, interferon-γ and interleukin-13 by soluble egg antigen or adult worm antigen stimulated cultures

  • Alda M.S Silveira

      Affiliations

    • Laboratório de Imunologia, Faculdade de Ciências da Saúde. Universidade Vale do Rio Doce, Governador Valadares, Brazil
    • ,
  • Giovanni Gazzinelli

      Affiliations

    • Santa Casa de Misericódia, Belo Horizonte, MG, Brazil
    • Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima 1715, 30190-002 Belo Horizonte, MG, Brazil
    • ,
  • Lúcia F Alves-Oliveira

      Affiliations

    • Laboratório de Imunologia, Faculdade de Ciências da Saúde. Universidade Vale do Rio Doce, Governador Valadares, Brazil
    • ,
  • Jeffrey Bethony

      Affiliations

    • Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA
    • ,
  • Andrea Gazzinelli

      Affiliations

    • Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    • ,
  • Claudia Carvalho-Queiroz

      Affiliations

    • Department of Microbiology, School of Medicine and Biomedical Sciences, Buffalo, New York, USA
    • ,
  • Maria Carolina B Alvarez

      Affiliations

    • Santa Casa de Misericódia, Belo Horizonte, MG, Brazil
    • ,
  • Francisco C Lima-Silva

      Affiliations

    • Santa Casa de Misericódia, Belo Horizonte, MG, Brazil
    • ,
  • Aluizio Prata

      Affiliations

    • Medicina Tropical, Faculdade de Medicina do Triângulo Mineiro, Uberaba, MG, Brazil
    • ,
  • Philip T LoVerde

      Affiliations

    • Department of Microbiology, School of Medicine and Biomedical Sciences, Buffalo, New York, USA
    • ,
  • Rodrigo Correa-Oliveira

      Affiliations

    • Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima 1715, 30190-002 Belo Horizonte, MG, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55-31-3295-3566; fax: +55-31-3295-3115.

Received 1 July 2003 ,Revised 10 November 2003 ,Accepted 20 November 2003.

References 

  1. Arap-Siongok TK, Mahmoud AAF, Ouma JH, Warren KE, Muller AE, Handa AK, et al. Morbidity in schistosomiasis mansoni in relation to intensity of infection: study of a community in Machakos, Kenya. Am. J. Trop. Med. Hyg. 1976;25:273–284
  2. Bethony J, Silveira AMS, Alves-Oliveira LF, Thakur A, Gazzinelli G, Correa-Oliveira R, et al. Familial resemblance in humoral immune response to defined and crude Schistosoma mansoni antigens in an endemic area in Brazil. J. Infect. Dis. 1999;173:1665–1673
  3. Butterworth AE, Capron M, Cordingley JS, Dalton PR, Dunne DW, Kariuki HC, et al. Immunity after treatment of human schistosomiasis mansoni. II. Identification of resistant individuals, and analysis of their immune response. Trans R. Soc. Trop. Med. Hyg. 1985;79:393–408
  4. Chiaramonte MG, Mentink-Kane M, Jacobson BA, Cheever AW, Whitters MJ, Goad ME, et al. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J. Exp. Med. 2003;197:675–679
  5. Dessein AJ, Couissinier P, Demeure C, Rihet P, Kohlstaedt S, Carneiro-Carvalho D, et al. Environmental genetic and immunological factors in human resistance to Schistosoma mansoni. Immunol. Invest. 1992;21:423–453
  6. Gazzinelli A, Bethony J, Alves-Oliveira LF, LoVerde PT, Correa-Oliveira R, Kloos H. Exposure to Schistosoma mansoni infection in a rural area of Brazil Part I: Water contact. Trop. Med. Int. Health. 2001;6:126–135
  7. Gryseels B. Human resistance to Schistosoma infections: age or experience?. Parasitol. Today. 1994;10:380–384
  8. Gryzch JM, Pearce EJ, Cheever AW, Caulada ZA, Caspar P, Hieny S, et al. Egg deposition is a major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J. Immunol. 1991;146:1322–1327
  9. Katz N, Chaves A, Pellegrino J. A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni. Rev. Inst. Med. Trop. São Paulo. 1972;14:397–400
  10. King CL, Medhat A, Malhotra I, Nafeh M, Helmy A, Khaudary J, et al. Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. J. Immunol. 1996;156:4715–4721
  11. Malaquias LCC, Falcão PL, Silveira AMS, Gazzinelli G, Prata A, Coffmann RL, et al. Cytokine regulation of human response to Schistosoma mansoni: analysis of the role of IL-4, IL-5 and IL-10 on peripheral blood mononuclear cells responses. Scand. J. Immunol. 1997;46:393–398
  12. Montenegro SML, Miranda P, Mahanty S, Abath FGC, Teixeira KM, Coutinho EM, et al. Cytokine production in acute versus chronic human schistosomiasis mansoni: the cross-regulatory role of interferon-γ and interleukin-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens. J. Inf. Dis. 1999;179:1502–1514
  13. Pearce EJ, Caspar P, Gryzch JM, Lewis FA, Sher A. Down regulation of Th1 cytocine production accompanies induction of Th2 responses by a helminth, Schistosoma mansoni. J. Exp. Med. 1991;173:159–166
  14. Sher A, Fiorentino D, Caspar P, Pearce E, Mosmann T. Production of IL-10 by CD4+ T lymphocytes corelates with downregulation of Th1 cytokine synthesis in helminth infection. J. Immunol. 1991;147:2713–2716
  15. Silveira AMS, Bethony J, Gazzinelli A, Kloos H, Alves-Oliveira LF, Alves MCB, et al. High levels of IgG4 to Schistosoma mansoni egg antigens are observed in individuals with periportal fibrosis. Am. J. Trop. Med. Hyg. 2002;66:542–549
  16. Viana IRC, Sher A, Carvalho OS, Massara CL, Eloi-Santos SM, Pearce EJ, et al. Interferon-γ production by peripheral blood mononuclear cells from residents of an area endemic for Schistosoma mansoni. Trans. R. Soc. Trop. Med. Hyg. 1994;88:466–470
  17. Vella AT, Pearce EJ. The CD4+ Th2 response induced by Schistosoma mansoni eggs rapidly develops through an early, transient Th0-like stage. J. Immunol. 1992;148:2283–2290
  18. Zwingenberger K, Hohmann A, Cardoso de Brito M, Ritter M. Impaired balance of interleukin-4 and interferon-γ production in infections with Schistosoma mansoni and intestinal nematodes. Scand. J. Immunol. 1991;34:234–251

PII: S0035-9203(04)00081-1

doi: 10.1016/j.trstmh.2003.11.009

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 98, Issue 9 , Pages 514-519 , September 2004

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