Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 98, Issue 9 , Pages 509-513 , September 2004

Artemether in the treatment of falciparum malaria during pregnancy in eastern Sudan

  • Ishag Adam

      Affiliations

    • New Halfa Teaching Hospital, P.O. Box 61, New Halfa, Sudan
    • Corresponding Author InformationCorresponding author. Tel.: +249-421-22101/21880; fax: +249-421-22070.
  • ,
  • Eltaib Elwasila

      Affiliations

    • New Halfa Teaching Hospital, P.O. Box 61, New Halfa, Sudan
  • ,
  • Daw Alnour Mohammed Ali

      Affiliations

    • New Halfa Teaching Hospital, P.O. Box 61, New Halfa, Sudan
  • ,
  • Elhassan Elansari

      Affiliations

    • Faculty of Medicine, University of Kassalla, Kassalla, Sudan
  • ,
  • Mustafa Idris Elbashir

      Affiliations

    • Faculty of Medicine, University of Khartoum, Khartoum, Sudan

Received 29 July 2003 ,Revised 30 October 2003 ,Accepted 12 November 2003.

References 

  1. Adam I, Elhadi M, Ahmed G, Elbashir M. In Sudan chloroquine resistance is worsening and quinine resistance is emerging. Sudan Med. J. 2001;39:5–11
  2. Adam I, Idris H, Mohamed-Ali AA, Aelbasit IA, Elbashir MI. Quinine versus artemether in the treatment of severe falciparum in Sudanese children. East Afr. Med. J. 2002;79:621–625
  3. Adam, I., Mirghani, O.M., Saed, O.K., Ahmed, S.M., Mohamadani, A.A., Ahmed, H.M., Mackenzie, C.D., Homeida, M.M., Elbashir, M.I. Quinine therapy in severe Plasmodium falciparum malaria during pregnancy in Sudan. East Mediterr. Health J, in press.
  4. Brabin BJ. Analysis of malaria in pregnancy in Africa. Bull. World Health Organ. 1983;61:1005–1016
  5. Brewer TG, Grate SJ, Peggins JO, Weina PJ, Petras JM, Levins BS, et al. Fatal neurotoxicity of arteether and artemether. Am. J. Trop. Med. Hyg. 1994;51:251–259
  6. Dafallah SE, El-Agib FH, Bushra GO. Maternal mortality in a teaching hospital in Sudan. Saudi Med. J. 2003;24:369–373
  7. Deen JL, von Seidlein L, Pinder M, Walraven GEL, Greenwood BM. The safety of the combination artesunate and pyrimethamine–sulfadoxine given during pregnancy. Trans. R. Soc. Trop. Med. Hyg. 2001;95:424–428
  8. Elhassan IM, Satti GMH, Ali AE, Fadul I, Elkhalifa AA, Abedelrahim AM, et al. The efficacy of artemether in the treatment of Plasmodium falciparum malaria in Sudan. Trans. R. Soc. Trop. Med. Hyg. 1993;87:685–686
  9. Elkheir HK, Elkarim EI, Eltayeb IB, Elkadaru AE, Babiker HA, Ibrahim AM. Efficacy of sulphadoxine and pyrimethamine, doxycycline and their combination in the treatment of chloroquine resistant falciparum malaria. Saudi Med. J. 2001;22:690–693
  10. Looarseesuwan, S., Phillips, R.E., White, N.J., Kietinum, S., Karbwang, J., Rackow, C., Turner, R.C., Warrell, D.A., 1985. Quinine and severe falciparum malaria in late pregnancy. Lancet (ii), 4–5.
  11. Marshal K. Malaria disaster in Africa. Lancet. 1998;352:924
  12. McGready R, Cho T, Hkirijaroen L, Simpson J, Chongsuphajaisiddhi T, White NJ, et al. Quinine and mofloquine in the treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy. Ann. Trop. Med. Parasitol. 1998;92:643–653
  13. McGready R, Cho JJ, Simpson J, Luxemburger C, Dubowitz L, Looareesuwan S, et al. Artesunate in the treatment of multi-drug resistant Plasmodium falciparum malaria in pregnancy. Trans. R. Soc. Trop. Med. Hyg. 1998;94:440–443
  14. McGready R, Brockman A, Cho T, Cho D, van Vugt M, Luxemburger C, et al. Randomized comparison of mefloquine-artesunate versus quinine in the treatment of multi-drug resistant Plasmodium falciparum malaria in pregnancy. Trans. R. Soc. Trop. Hyg. 2000;94:689–693
  15. McGready R, Cho T, Keo NK, Thwai KL, Villegas L, Looareesuwan ST, et al. Artemisinin antimalarials in pregnancy: A Prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum. Clin. Infect. Dis. 2001;33:2009–2016
  16. McGregor IA, Wilson ME, Billewicz WZ. Malaria infection of the placenta in Gambia, West Africa it is incidence and relationship to stillbirth, birthweight and placental weight. Trans. R. Soc. Trop. Med. Hyg. 1983;77:232–244
  17. McGregor IA. Epidemiology, malaria and pregnancy. Am. J. Trop. Med. Hyg. 1984;33:517–525
  18. Nosten F, ter Kuile FO, Maelankirri L, Decludt B, White NJ. Malaria during pregnancy in an area of unstable endimicity. Trans. R. Soc. Trop. Med. Hyg. 1991;85:424–429
  19. Nosten F, Vincenti M, Simpson J, Yei P, Thwai KL, de Vries A, et al. The effect of mefloquine treatment in pregnancy. Clin. Infect. Dis. 1999;28:808–815
  20. Olsen BE, Hinderaker SG, Bergsjo P, Lie RT, Olsen OH, Kasheka P, et al. Causes and characteristics of maternal deaths in rural northern Tanzania. Acta. Obstet. Gynecol. Scand. 2002;81:1101–1109
  21. Skinner TS, Manning LS, Jonhston WA, Davis TM. In vitro stage specific sensitivity of Plasmodium falciparum to quinine and artemether drugs. Int. J. Parasitol. 1996;226:519–525
  22. Steketee RW, Nahlen BL, Parise MF, Menendez C. The burden of malaria in pregnancy in malaria-endemic areas. Am. J. Trop. Med. Hyg. 2001;64(Suppl):28–35
  23. Taha ET, Ronald HG, Abdalla AM. Malaria and low birth weight in central Sudan. Am. J. Epidemiol. 1993;138:315–325
  24. Uche-Nwachi EO, Caxton-Martin AE. Sulaphdoxine–pyrimethamine embryopathy in Wistar rats. Kaibogaku Zassashi. 1998;73:135–139
  25. White NJ. Antimalarial drug resistance: the pace quickens. J. Antimicrob. Chemother. 1992;30:571–585
  26. WHO, 1986. WHO expert committee on malaria, 18th report. World Health Organization, Geneva, Technical Report Series No. 735, 57–78.
  27. WHO, 1990. Severe and complicated malaria. Trans. R. Soc. Trop. Med. Hyg. 84, 2–3.
  28. WHO, 1994. The Role of artemisinin and its derivatives in the current treatment of malaria (1994–1995). World Heath Organization, Geneva, mimeographed document WHO/MAL/94.1067.

PII: S0035-9203(04)00080-X

doi: 10.1016/j.trstmh.2003.11.008

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 98, Issue 9 , Pages 509-513 , September 2004