Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 98, Issue 5 , Pages 311-314, May 2004

Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar

  • M.L Willcox

      Affiliations

    • Institut Malgache de Recherches Appliquées, BP 3833, Antananarivo 101, Madagascar
    • Laboratoire de Parasitologie et Bactériologie, Service de Santé de District, Ankazobe 108, Madagascar
    • Research Initiative for Traditional Antimalarial Methods, 36 Hare Close, Buckingham MK18 7EW, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44-1280-814103.
    • ,
  • E Rakotondrazafy

      Affiliations

    • Laboratoire de Parasitologie et Bactériologie, Service de Santé de District, Ankazobe 108, Madagascar
    • ,
  • R Andriamanalimanana

      Affiliations

    • Institut Malgache de Recherches Appliquées, BP 3833, Antananarivo 101, Madagascar
    • Service de Réanimation, CHU–HJRA, Ampefiloha, Antananarivo 101, Madagascar
    • ,
  • D Andrianasolo

      Affiliations

    • Institut Malgache de Recherches Appliquées, BP 3833, Antananarivo 101, Madagascar
    • Service de Réanimation, CHU–HJRA, Ampefiloha, Antananarivo 101, Madagascar
    • ,
  • P Rasoanaivo

      Affiliations

    • Institut Malgache de Recherches Appliquées, BP 3833, Antananarivo 101, Madagascar
    • Research Initiative for Traditional Antimalarial Methods, 36 Hare Close, Buckingham MK18 7EW, UK

Received 7 July 2003; received in revised form 7 October 2003; accepted 13 October 2003.

Abstract 

The clinical efficacy of chloroquine was assessed in the Primary Health Centre of Ankazobe, Central Highlands of Madagascar. This study shows an increase in the level of chloroquine resistance with the appearance of early treatment failures and RIII resistance. Furthermore, the prevalence of clinical treatment failures is approaching the level of 25%, at which WHO recommends a change of first-line drug.

Keywords:  Malaria, Chloroquine, Clinical efficacy, Drug resistance, Madagascar Highlands

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PII: S0035-9203(04)00002-1

doi:10.1016/j.trstmh.2003.10.002

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 98, Issue 5 , Pages 311-314, May 2004

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