Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 97, Issue 6 , Pages 687-691 , November 2003

Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hepatic dysfunction

  • Joon-Sup Yeom

      Affiliations

    • Department of Internal Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Pyung-Dong 108, Jongro-Ku, Seoul 110-746, Republic of Korea
  • ,
  • Se-Ho Park

      Affiliations

    • Department of Occupational Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Pyung-Dong 108, Jongro-Ku, Seoul 110-746, Republic of Korea
  • ,
  • Seung-Ho Ryu

      Affiliations

    • Graduate School of Biotechnology, Korea University, Anam-Dong, Sungbuk-Gu, Seoul 136-701, Republic of Korea
  • ,
  • Hae-Kyung Park

      Affiliations

    • Department of Microbiology,College of Medicine, Ewha Womans University, Mok-6-Doug 911-1, Yangchon-Gu, Seoul 158-710, Republic of Korea
  • ,
  • So-Youn Woo

      Affiliations

    • Department of Microbiology,College of Medicine, Ewha Womans University, Mok-6-Doug 911-1, Yangchon-Gu, Seoul 158-710, Republic of Korea
  • ,
  • Eun-Hee Ha

      Affiliations

    • Department of Preventive Medicine, College of Medicine, Ewha Womans University, Mok-6-Doug 911-1, Yangchon-Gu, Seoul 158-710, Republic of Korea
  • ,
  • Bo-Eun Lee

      Affiliations

    • Department of Preventive Medicine, College of Medicine, Ewha Womans University, Mok-6-Doug 911-1, Yangchon-Gu, Seoul 158-710, Republic of Korea
  • ,
  • Kwon Yoo

      Affiliations

    • Department of Internal Medicine, College of Medicine, Ewha Womans University, Mok-6-Doug 911-1, Yangchon-Gu, Seoul 158-710, Republic of Korea
  • ,
  • Joo-Ho Lee

      Affiliations

    • Department of Surgery, College of Medicine, Ewha Womans University, Mok-6-Doug 911-1, Yangchon-Gu, Seoul 158-710,Republic of Korea
  • ,
  • Kwang-Ho Kim

      Affiliations

    • Department of Microbiology, Gachon Medical School, Kuwol-l-Dong 1198, Namdong-Gu, Inchon 405-760, Republic of Korea
  • ,
  • Sunhil Kim

      Affiliations

    • Department of Microbiology, Gachon Medical School, Kuwol-l-Dong 1198, Namdong-Gu, Inchon 405-760, Republic of Korea
  • ,
  • Young-A Kim

      Affiliations

    • Department of Microbiology, Gachon Medical School, Kuwol-l-Dong 1198, Namdong-Gu, Inchon 405-760, Republic of Korea
  • ,
  • Sun-Young Ahn

      Affiliations

    • Department of Microbiology, Gachon Medical School, Kuwol-l-Dong 1198, Namdong-Gu, Inchon 405-760, Republic of Korea
  • ,
  • Sejoong Oh

      Affiliations

    • Korean Armed Forces Medical Command, Yool-Dong, Boondang-Gu, Seongnam, Kyonggi-Do463-040, Republic of Korea
  • ,
  • Hyung-Joo Park

      Affiliations

    • Korean Armed Forces Medical Command, Yool-Dong, Boondang-Gu, Seongnam, Kyonggi-Do463-040, Republic of Korea
  • ,
  • Gi-Sik Min

      Affiliations

    • Department of Biological Sciences, Inha University, Yonghyun-Dong 253, Nam-Gu, Inchon 402-751, Republic of Korea
  • ,
  • Ju-Young Seoh

      Affiliations

    • Department of Microbiology,College of Medicine, Ewha Womans University, Mok-6-Doug 911-1, Yangchon-Gu, Seoul 158-710, Republic of Korea
    • Corresponding Author InformationAddresses for correspondence: Dr Ju-Young Seoh, Department of Microbiology, College of Medicine, Ewha Womans University, Mok-6-Dong 911-1, Yangchon-Gu, Seoul 158-710, South Korea; phone +82 22 650 5738, fax +82 22 653 8891
  • ,
  • Jae-Won Park

      Affiliations

    • Department of Microbiology, Gachon Medical School, Kuwol-l-Dong 1198, Namdong-Gu, Inchon 405-760, Republic of Korea
    • Corresponding Author InformationDr Jae-Won Park, Department of Microbiology, Gachon Medical School, 1198, Kuwol-1-Dong, Namdong-Gu, Inchon 405-760, South Korea; phone +82 32 460 2184, fax + 82 32 930 5088

Received 9 October 2002 ,Revised 24 March 2003 ,Accepted 3 April 2003.

References 

  1. Alexander J, Stimson WH. Sex hormones and the course of parasitic infection. Parasitology Today. 1988;4:189–193
  2. Blatteis CM, Sehic E, Li S. Pyrogen sensing and signaling: old views and new concepts. Clinical Infectious Diseases. 2000;31:S168–S177
  3. Bradford VP, Graham BP, Reinert KG. Accuracy of self-reported health histories: a study. Military Medicine. 1993;158:263–265
  4. Brown AE, Teja-Isavadharm P, Webster HK. Macrophage activation in vivax malaria: fever is associated with increased levels of neopterin and interferon-gamma. Parasite Immunology. 1991;13:673–679
  5. Butcher GA, Garland T, Ajdukiewicz AB, Clark IA. Serum tumor necrosis factor associated with malaria in patients in the Solomon Islands. Transactions of the Royal Society for Tropical Medicine and Hygiene. 1990;84:658–661
  6. Chai JY. Re-emerging Plasmodium vivax malaria in the Republic of Korea. Korean Journal of Parasitology. 1999;37:129–143
  7. Day NPJ, Hien TT, Schollaardt T, Loc PP, Chuong LV, Chau TTH, et al. The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria. Journal of Infectious Diseases. 1999;180:1288–1297
  8. Dodoo D, Omer FM, Todd J, Akanmori BD, Koran KA, Riley EM. Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodiumfalciparum malaria. Journal of Infectious Diseases. 2002;185:971–979
  9. Field JW. Blood examination and prognosis in acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1949;43:33–48
  10. Hazra BR, Chowdhury RS, Saha SK, Ghosh MB, Mazumder AK. Changing scenario of malaria: a study at Calcutta. Indian Journal of Malariology. 1998;35:111–116
  11. Hiroyasu S, Shiraishi M, Koji T, Mamadi T, Sugawa H, Muto Y. Analysis of the Fas system and Bcl-2 in rat liver allograft rejection. Journal of Surgical Research. 1999;84:204–211
  12. Jason J, Archibald LK, Nwanyanwu OC, Bell M, Buchanan I, Larned J, et al. Cytokines and malaria parasitemia. Clinical Immunology. 2001;100:208–218
  13. Karunaweera ND, Carter R, Grau GE, Kwiatkowski D, Del Giudice G, Mendis KN. Tumour necrosis factor-dependent parasite-killing effects during paroxysms in non-immune Plasmodium vivax malaria patients. Clinical and Experimental Immunology. 1992;88:499–505
  14. Karunaweera ND, Grau GE, Gamage P, Carter R, Mendis KN. Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in Plasmodium vivax malaria. In: Proceedings of the National Academy of Sciences of the USA. 89:1992;p. 3200–3203
  15. Karunaweera ND, Carter R, Grau GE, Mendis KN. Demonstration of anti-disease immunity to Plasmodium vivax malaria in Sri Lanka using a quantitative method to assess clinical disease. American Journal of Tropical Medicine and Hygiene. 1998;58:204–210
  16. Kim MB. Epidemiologic characteristics of malaria in non-malarious area, Jeollabuk-do, Korea in 2000. Korean Journal of Parasitology. 2001;39:223–226
  17. Krosgstad DJ. Plasmodium species (Malaria). In: Bennet JE, Dolin R editor. Principles and Practice of Infectious Diseases. 5th edition. Churchill Livingstone; 2000;p. 2817–2831
  18. Liu TZ, Lee KT, Chern CL, Cheng JT, Stern A, Tsai LY. Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines andenhanced activation of nuclear factor kappaB. Annals of Clinical and Laboratory Sciences. 2001;31:383–390
  19. Malaguarnera L, Imbesi RM, Pignatelli S, Simpore J, Malaguarnera M, Musumeci S. Increased levels of interleukin-12 in Plasmodium falciparum malaria: correlation with the severity of disease. Parasite Immunology. 2002;24:387–389
  20. Malaguarnera L, Pignatelli S, Simpore J, Musumeco MM. Plasma levels of IL-12, Il-18 and TGF- in Plasmodium falciparum malaria. European Cytokine Network. 2002;13:425–430
  21. Miller KD, White NJ, Lott JA, Roberts JM, Greenwood BM. Biochemical evidence of muscle injury in African children with severe malaria. Journal of Infectious Diseases. 1989;159:139–142
  22. Moss DW. Enzymes. In: Burris CA, Ashwood ER editor. 2nd edition. Teitz Textbook of Clinical Chemistry. Philadelphia: Lea and Febiger; 1998;p. 167–203
  23. Netea MG, Kullberg BJ, Van der Meer JWM. Circulating cytokines as mediators of fever. Clinical Infectious Disease. 2000;31:S178–S184
  24. Newton CR, Krishna S. Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacological Therapeutics. 1998;79:1–53
  25. Park JW, Moon SH, Yeom JS, Lim KJ, Sohn MJ, Jung WC, et al. Naturally acquired antibody responses to the C-terminal region of merozoite surface protein 1 of Plasmodium vivax in Korea. Clinical and Diagnostic Laboratory Immunology. 2001;8:14–20
  26. Perkins D, Weinberg J, Kremsner P. Reduced interleukin-12 and transforming growth factor-1 in severe childhood malaria: relationship of cytokine balance with disease severity. Journal of Infectious Diseases. 2000;182:988–992
  27. Ramachandran S, Perera MV. Jaundice and hepatomegaly in primary malaria. Journal of Tropical Medicine and Hygiene. 1976;79:207–210
  28. Ramadori G, Armbrust T. Cytokines in the liver. European Journal of Gastroenterology and Hepatology. 2001;13:777–784
  29. Richards AL. Tumor necrosis factor and associated cytokines in the host's response to malaria. International Journal for Parasitology. 1997;27:1251–1263
  30. Roth J, Martin D, Storr B, Zeisberger E. Neutralization of pyrogen-induced tumor necrosis factor by its type 1 soluble receptor in guinea pigs: effects on fever and interleukin-6 release. Journal of Physiology. 1998;509:267–275
  31. Seoh JY, Khan M, Park SH, Park HK, Shin MH, Ha EH, et al. Serum cytokine profiles in patients with Plasmodium vivax malaria: a comparison between those who presented with and without hyperpyrexia. American Journal of Tropical Medicine and Hygiene. 2003;68:102–106
  32. Taylor TE, Molyneux ME, Wirima JJ, Fletcher KA, Morris K. Blood glucose levels in Malawian children before and during the administration of intravenous glucose for severe falciparum malaria. New England Journal of Medicine. 1988;319:1040–1047
  33. Tiegs G. Experimental hepatitis and role of cytokines. Acta Gastroenterologica Belgium. 1997;60:176–179
  34. Torre D, Speranza F. Transforming growth factor-β, interleukin (IL)-18, and IL-12: effect on the clinical course and complications of Plasmodium falciparum malaria. Journal of Infectious Diseases. 2003;187:338–339
  35. Turner EL, Bent MJ, Holloway GD. Nutritional deficiency as an etiological factor in icterus accompanying pneumonia in the Negores. Southern Medical Journal. 1943;36:603–608
  36. Walley KR, Lukacs NW, Standiford TJ, Strieter RM, Kunkel SL. Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infection and Immunity. 1996;64:4733–4738
  37. White NJ, Warrell DA. Severe hypoglycemia and hyperinsulinemia in falciparum malaria. New England Journal of Medicine. 1983;309:61–66
  38. WHO . Severe and complicated malaria, 2nd edition. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1990;84(supplement 2):
  39. Yoshika TT, Turner JA. Common protozoan infections. In: Yoshika TT, Chow AW, Guzz LB editor. Infectious Diseases: Diagnosis and Management. John Wiley & Sons; 1980;p. 613–633

PII: S0035-9203(03)80104-9

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 97, Issue 6 , Pages 687-691 , November 2003