Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 96, Issue 4 , Pages 418-420 , July 2002

Chloroquine resistance of Plasmodium falciparum is associated with severity of disease in Nigerian children

  • P.E. Olumese

      Affiliations

    • Corresponding Author InformationAddress for correspondence: Dr P. E. Olumese, Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria.
    • Department of Clinical Pharmacology University College Hospital, Ibadan, Nigeria
    • Department of Paediatrics, University College Hospital, Ibadan, Nigeria
    • Division of Infectious Diseases, Karolinska Institute, Stockholm, Sweden
    • ,
  • O.K. Amodu

      Affiliations

    • Department of Zoology, University of Ibadan, Ibadan, Nigeria
    • ,
  • A. Björkman

      Affiliations

    • Division of Infectious Diseases, Karolinska Institute, Stockholm, Sweden
    • ,
  • A.A. Adeyemo

      Affiliations

    • Department of Paediatrics, University College Hospital, Ibadan, Nigeria
    • ,
  • R.A. Gbadegesin

      Affiliations

    • Department of Paediatrics, University College Hospital, Ibadan, Nigeria
    • ,
  • O. Walker

Received 15 May 2001 ,Revised 26 September 2001 ,Accepted 1 October 2001.

References 

  1. Björkman A, Phillips-Howard PA. The epidemiology of drug-resistant malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1990;84:177–180
  2. Falade CO, Salako LA, Sowunmi A, Oduola AMJ, Larcier P. Comparative efficacy of halofantrine, chloroquine and sulfadoxine-pyrimethamine for treatment of acute uncomplicated falciparum malaria in Nigerian children. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1997;91:58–62
  3. Mockenhaupt FP, May J, Bergqvist Y, Ademowo OG, Olumese P, Falusi AG, et al. Blood concentration of chloroquine and malaria parasites in Nigerian children. Antimicrobial Agents and Chemotherapy. 2000;44:835–839
  4. Pasvol G, Clough B, Carlsson J, Snounou G. The pathogenesis of severe falciparum malaria. Baillière's Clinical Infectious Diseases. 1995;2:249–270
  5. Rosario VE, Hall R, Walliker D, Beale GH. Persistence of drug-resistant malaria parasites. Lancet. 1978;i:185–187
  6. Thaithong S, Beale GH, Chutmongkonkul M. Susceptibility of Plasmodium falciparum to five drugs: an in vitro study of isolates mainly from Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1983;77:228–231
  7. Trape JF, Pison G, Preziosi MP, Enel C, Desgrees du Lou A, Delaunay V, et al. Impact of chloroquine resistance on malaria mortality. Comptes Rendus Hebdomadaires des Séances de l'Académie des Sciences, Paris, Série III. 1998;321:689–697
  8. Wernsdorfer WH, Landgraf B, Wiedermann G, Kollaritsch H. Chloroquine resistance of Plasmodium falciparum: a biological advantage?. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1995;89:90–91
  9. WHO . In vitro micro-test (Mak II) for the assessment of the response of Plasmodium falciparum to chloroquine, mefloquine, quinine, sulfadoxine/pyrimethamine and amodiaquine. In: Mimeographed document MAP/87.2. Geneva: World Health Organization; 1987;
  10. WHO . Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2000;94(supplement 1):

PII: S0035-9203(02)90378-0

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 96, Issue 4 , Pages 418-420 , July 2002

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