Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 96, Issue 4 , Pages 418-420, July 2002

Chloroquine resistance of Plasmodium falciparum is associated with severity of disease in Nigerian children

  • P.E. Olumese

      Affiliations

    • Corresponding Author InformationAddress for correspondence: Dr P. E. Olumese, Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria.
    • Department of Clinical Pharmacology University College Hospital, Ibadan, Nigeria
    • Department of Paediatrics, University College Hospital, Ibadan, Nigeria
    • Division of Infectious Diseases, Karolinska Institute, Stockholm, Sweden
    • ,
  • O.K. Amodu

      Affiliations

    • Department of Zoology, University of Ibadan, Ibadan, Nigeria
    • ,
  • A. Björkman

      Affiliations

    • Division of Infectious Diseases, Karolinska Institute, Stockholm, Sweden
    • ,
  • A.A. Adeyemo

      Affiliations

    • Department of Paediatrics, University College Hospital, Ibadan, Nigeria
    • ,
  • R.A. Gbadegesin

      Affiliations

    • Department of Paediatrics, University College Hospital, Ibadan, Nigeria
    • ,
  • O. Walker

Received 15 May 2001; received in revised form 26 September 2001; accepted 1 October 2001.

Abstract 

Chloroquine resistance of Plasmodium falciparum in vitro was significantly higher in isolates from patients with severe malaria than those with uncomplicated disease. This association may be due to either progression of uncomplicated to severe disease following chloroquine failure or increased virulence of chloroquine-resistant parasites. The implication of this for antimalarial treatment policy is discussed.

Keywords:  malaria, Plasmodium falciparum, chemotherapy, chloroquine resistance, parasite virulence, pathogenesis, Nigeria

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PII: S0035-9203(02)90378-0

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 96, Issue 4 , Pages 418-420, July 2002

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