Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 96, Issue 4 , Pages 411-417 , July 2002

Glucose and lactate turnover in adults with falciparum malaria: effect of complications and antimalarial therapy

  • Timothy M.E. Davis

      Affiliations

    • Corresponding Author InformationAddress for correspondence: Professor T. M. E. Davis, University of Western Australia, Department of Medicine, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6959, Australia; phone +61 8 9431 3229, fax +61 8 9431 2977.
    • niversity of Western Australia, Department of Medicine, Fremantle Hospital, Fremantle, Australia
  • ,
  • Tran Quang Binh

      Affiliations

    • Tropical Diseases Research Centre, Cho Ray Hospital, Ho Chi Minh City, Viet Nam
  • ,
  • Le Thi Anh Thu

      Affiliations

    • Tropical Diseases Research Centre, Cho Ray Hospital, Ho Chi Minh City, Viet Nam
  • ,
  • Ton That Ai Long

      Affiliations

    • Tropical Diseases Research Centre, Cho Ray Hospital, Ho Chi Minh City, Viet Nam
  • ,
  • Wayne Johnston

      Affiliations

    • niversity of Western Australia, Department of Medicine, Fremantle Hospital, Fremantle, Australia
  • ,
  • Ken Robertson

      Affiliations

    • Biochemistry Department, Royal Perth Hospital, Perth, Australia
  • ,
  • P.Hugh R. Barrett

      Affiliations

    • niversity of Western Australia, Department of Medicine, Fremantle Hospital, Fremantle, Australia

Received 26 November 2001 ,Revised 11 February 2002 ,Accepted 11 February 2002.

References 

  1. Agbenyega T, Angus BJ, Bedu-Addo G, Baffoe-Bonnie B, Guyton T, Stacpoole PW, et al. Glucose and lactate kinetics in children with severe malaria. Journal of Clinical Endocrinology and Metabolism. 2000;85:1569–1576
  2. Beaufort-Krol GCM, Takens J, Bijsterveld K, Nagel GT, Kuipers JRG. The presence of lactate in the derivatization agent N-methyl-N-(tert-butyldimethyl-silyl)-trifluoroacetamide: a problem in the determination of [13C1]lactate. Journal of Mass Spectrometry. 1996;31:1061–1063
  3. Bier DM. Investigation with stable isotopes. In:  Alberti KGMM,  Home PD,  Taylor R editor. Techniques for Metabolic Investigation in Man. Clinical Endocrinology and Metabolism. 1:1987;p. 819–836
  4. Binh TQ, Davis TME, Johnston W, Thu LTA, Boston R, Danh PT, et al. Minimal model analysis of the intravenous glucose tolerance test incorporating a stable glucose label. Metabolism. 1997;46:1435–1440
  5. Boyle PJ. Alteration in brain glucose metabolism induced by hypoglycaemia in man. Diabetologia. 1997;40:S69–S74
  6. Cobelli C, Toffolo G, Bier DM, Nosadini R. Models to interpret kinetic data in stable isotope tracer studies. American Journal of Physiology. 1987;253:E551–E564
  7. Davis TME, Looareesuwan S, Pukrittayakamee S, Levy JC, Nagachinta B, White NJ. Glucose turnover in severe falciparum malaria. Metabolism. 1993;42:334–340
  8. Davis TME, Suputtamongkol Y, Spencer J, Wilson S, Mekhton S, Croft KD, et al. Glucose turnover in pregnant women with acute malaria. Clinical Science. 1994;86:83–90
  9. Davis TME, Benn JJ, Suputtamongkol Y, Weinberg J, Umpleby AM, Chierakul N, et al. Lactate turnover and forearm lactate metabolism in severe falciparum malaria. Endocrinology and Metabolism. 1996;3:105–115
  10. Davis TME, Pongponratan E, Supanaranond W, Pukrittayakamee S, Helliwell T, Holloway P, et al. Skeletal muscle involvement in falciparum malaria: biochemical and ultrastructural study. Clinical Infectious Diseases. 1999;29:831–835
  11. Davis TME, Supanaranond W, Pukrittayakamee S, Holloway P, Chubb P, White NJ. Progression of skeletal muscle damage during treatment of severe falciparum malaria. Acta Tropica. 2000;76:271–276
  12. Day NP, Phu NH, Mai NT, Chau TT, Loc PP, Chuong LV, et al. The pathophysiologic and prognostic significance of acidosis in severe adult malaria. Critical Care Medicine. 2000;28:1833–1840
  13. Gribble FM, Davis TME, Higham CE, Clark A, Ashcroft FM. The antimalarial agent mefloquine inhibits ATP-sensitive K-channels. British Journal of Pharmacology. 2000;131:756–760
  14. Hien TT, Day NPJ, Nguyen HP, Nguyen TH, Tran TH, Pham PL, et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. New England Journal of Medicine. 1996;335:76–83
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  18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  19. Mazzeo RS, Brooks GA, Schoeller DA, Budinger TF. Disposal of blood [1-13C]lactate in humans during rest and exercise. Journal of Applied Physiology. 1986;60:232–241
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  23. Siegel S, Castellan NJ. In: Nonparametric Statistics for the Behavioural Sciences. New York: McGraw Hill; 1988;
  24. Singh B, Choo KE, Ibrahim J, Johnston W, Davis TME. Non-radioisotopic glucose turnover in children with falciparum malaria and enteric fever. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1998;92:532–537
  25. Van-Hensbroek MB, Onyiorah E, Jaffar S, Schnieder G, Palmer A, Frenkel J, et al. A trial of artemether or quinine in children with cerebral malaria. New England Journal of Medicine. 1996;335:69–75
  26. White NJ, Warrell DA, Chanthanvanich P, Looareesuwan S, Warrell MJ, Krishna S, et al. Severe hypoglycemia and hyperinsulinemia in falciparum malaria. New England Journal of Medicine. 1983;309:61–66
  27. WHO . Severe and complicated malaria. 2nd edn. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1990;84(supplement 2):
  28. Wood CD. Post-operative exercise capacity following nutritional support with hypotonie glucose. Surgery, Gynecology and Obstetrics. 1981;152:39–42

PII: S0035-9203(02)90377-9

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 96, Issue 4 , Pages 411-417 , July 2002