Leishmania (Viannia) spp. dissemination and tissue tropism in naturally infected dogs (Canis familiaris)

Reithinger, Richard; Lambson, Bronwen E.; Barker, Douglas C.; Counihan, Helen; Espinoza, Juan Canales; Gonzalez, Jamintong Sabino; Davies, Clive R.

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Volume 96, Issue 1 , Pages 76-78, January 2002

Leishmania (Viannia) spp. dissemination and tissue tropism in naturally infected dogs (Canis familiaris)

Richard Reithinger
- Author for correspondence: Disease Control and Vector Biology, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK; phone +44 (0)20 79272213, fax +44 (0)20 74679536.
- Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
- Molteno Institute for Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
Bronwen E. Lambson
- Molteno Institute for Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
Douglas C. Barker
- Molteno Institute for Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
Helen Counihan
- Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Juan Canales Espinoza
- Direccion Regional de Salud Huánuco, Damaso Beraún 1016, Huánuco, Peru
Jamintong Sabino Gonzalez
- Direccion Regional de Salud Huánuco, Damaso Beraún 1016, Huánuco, Peru
Clive R. Davies
- Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK

Received 11 May 2001; received in revised form 2 July 2001; accepted 5 July 2001.

Abstract

First evidence is presented for Leishmania (Viannia) spp. dissemination and tissue tropism in the domestic dog. Using PCR and histology, parasites were detected in the conjunctiva, lung, lymph nodes and ovaries of 2 naturally infected Peruvian dogs. The detection of parasites in the blood indicates that parasite dissemination to those organs may have been haematogenous.

Keywords: cutaneous leishmaniasis, Leishmania (Viannia), animal model, dog, PCR, molecular diagnostics, Peru

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