Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 96, Supplement 1 , Pages S49-S54, April 2002

Genes coding structural proteins in the Leishmania braziliensis complex☆

  • C. Padilla

      Affiliations

    • Instituto National de Salud, Centro Nacional de Laboratorios de Salud Pública, Lima, Perú
    • ,
  • T. Barreto

      Affiliations

    • Instituto National de Salud, Centro Nacional de Laboratorios de Salud Pública, Lima, Perú
    • ,
  • M. De Los Santos

      Affiliations

    • Instituto National de Salud, Centro Nacional de Laboratorios de Salud Pública, Lima, Perú
    • ,
  • D.C. Barker

      Affiliations

    • Molteno Laboratories, Department of Pathology, University of Cambridge, Cambridge, UK
    • ,
  • C. Carrillo

      Affiliations

    • Departamento de Microbiología, Universidad Peruana Cayetano Heredia, Lima, Perú
    • ,
  • Y. Montoya

      Affiliations

    • Corresponding Author InformationAddress for correspondence: Ysabel Montoya, Instituto Nacional de Salud, Centro Nacional de Laboratorios de Salud Pública, Jr Capac Yupanqui 1400, Jesus Maria, Lima, Perú; fax +511 471 9920 ext. 129.
    • Instituto National de Salud, Centro Nacional de Laboratorios de Salud Pública, Lima, Perú

Abstract 

Acidic ribosomal P1 and P2b proteins, referred to as P proteins, and histone H3 are reported for first time in the Leishmania braziliensis complex. Deoxyribonucleic acid analysis and multiple sequence alignment suggest that both P proteins may maintain their structural function in the ribosomal stalk, in spite of the high rate of mutations detected. The deduced amino acid sequence of protein P1 showed 51% identity with Trypanosoma cruzi protein P1 and protein P2b showed 61% identity with T. cruzi protein P2b. Another conserved protein, L. (Viannia) braziliensis histone H3, showed 82% and 70% identity with histone H3 of L. (Leishmania) infantum and T. cruzi, respectively. The N-terminal end of this histone is divergent in comparison with the consensus eukaryotic sequence. Their predicted tridimensional structure was designed.

Keywords:  leishmaniasis, Leishmania braziliensis, Leishmania peruviana, acidic ribosomal proteins, histone H3

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☆ Nucleotide sequence data reported in this paper have been submitted to the GenBank/EMBL/DDBJ data base with accession numbers AF045249, AF045020 and AF044682.

PII: S0035-9203(02)90051-9

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 96, Supplement 1 , Pages S49-S54, April 2002

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