Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 65, Issue 3 , Pages 331-333, 1971

Treatment of schistosomiasis mansoni with hycanthone in glucose-6-phosphate dehydrogenase deficiency in St. Lucia☆

  • J.A. Cook

      Affiliations

    • Staff member, The Rockefeller Foundation.

Massachusetts General Hospital, Boston, USA

Research and Control Department, Castries, St. Lucia, W.I., USA

Abstract 

G6PD deficiency was detected in 63 (14·8%) of 427 male children on St. Lucia screened for this condition.

8 G6PD-deficient and 6 non-deficient children, all infected with S. mansoni, were given a single intramuscular dose (3 mg./kg. body weight) of hycanthone, a drug structurally similar to others that cause haemolysis in persons with G6PD deficiency. Serial haematocrit and reticulocyte counts showed no evidence of haemolysis in either group.

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☆ This study was made while the senior author was a medical student in the Harvard Training Program in tropical medicine, supported by USPHS Grant No. AI-00177.

PII: 0035-9203(71)90008-3

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 65, Issue 3 , Pages 331-333, 1971

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