Treatment of schistosomiasis mansoni with hycanthone in glucose-6-phosphate dehydrogenase deficiency in St. Lucia☆
Abstract
G6PD deficiency was detected in 63 (14·8%) of 427 male children on St. Lucia screened for this condition.
8 G6PD-deficient and 6 non-deficient children, all infected with S. mansoni, were given a single intramuscular dose (3 mg./kg. body weight) of hycanthone, a drug structurally similar to others that cause haemolysis in persons with G6PD deficiency. Serial haematocrit and reticulocyte counts showed no evidence of haemolysis in either group.
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Massachusetts General Hospital, Boston, USA
Research and Control Department, Castries, St. Lucia, W.I., USA
☆ This study was made while the senior author was a medical student in the Harvard Training Program in tropical medicine, supported by USPHS Grant No. AI-00177.
ABSTRACT