Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 54, Issue 3 , Pages 270-273, May 1960

Treatment of tetanus with acetylpromazine

  • R. Wright, M.B. CH.B.

      Affiliations

    • I wish to thank Professor E. B. Adams for his encouragement and advice, Dr. D. R. Laurence who suggested using acetylpromazine and Benger Laboratories Ltd. for supplies of the drug; Dr. N. M. Mann for his assistance, and Dr. S. Disler, medical superintendent, and members of the nursing staff of King Edward VIII Hospital, for their co-operation.

Department of Medicine, University of Natal and King Edward VIII Hospital, Durban, South Africa

Abstract 

1.1) A phenothiazine derivative, acetylpromazine, has been used in eight non-neonatal and 25 neonatal cases of severe tetanus, either alone or in combination with phenobarbitone sodium.

2.2) It has been shown to be effective in reducing muscular rigidity and controlling reflex spasms, and experimental evidence of greater potency than chlorpromazine has been confirmed.

3.3) The limitations of this type of therapy in very severe cases with respiratory failure are emphasized.

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PII: 0035-9203(60)90074-2

Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 54, Issue 3 , Pages 270-273, May 1960

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